Human Leucocyte Antigens in Patients with Alcoholic Liver Cirrhosis

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Abstract
No significant differences in the frequencies of HLA-B8, -B40 and other HLA-A, -B and -C phenotypes were found among patients with histologically verified alcoholic cirrhosis compared with normal controls when the p values were multiplied by the number of comparisons. This was found both in the present study of 45 patients and in the combined data of this and 3 other similar studies. However, these findings do not rule out that alcoholic cirrhosis might be associated with HLA factors (e.g., HLA-D/DR antigens) controlling immune responses.