Iron—dextran antibody conjugates: General method for simultaneous staining of two components in high-resolution immunoelectron microscopy

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Abstract
The preparation and properties of an electron-dense antibody conjugate, made by the covalent bonding of an iron-dextran (Imposil) particle to an antibody molecule were reported. Transmission electron microscopic experiments with the Imposil-antibody conjugates demonstrated their suitability as specific immunostains at high resolution, particularly for simultaneous double staining experiments in conjunction with ferritin-antibody conjugates.