A New, Efficient, Two Step Procedure for the Preparation of the Antineoplastic Agent Sparfosic Acid
- 1 April 1997
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 27 (7) , 1259-1266
- https://doi.org/10.1080/00397919708003363
Abstract
Sparfosic acid can easily be prepared in two steps and in excellent yield from condensation of the commercially available starting materials L-aspartic acid di-tert-butyl ester hydrochloride and diethylphosphonoacetic acid, followed by a quadruple deprotection of acidic functions under mild conditions using bromotrimethylsilane.Keywords
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