Reduction of false positives in lung nodule detection using a two-level neural classification

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Abstract
The authors have developed a neural-digital computer-aided diagnosis system, based on a parameterized two-level convolution neural network (CNN) architecture and on a special multilabel output encoding procedure. The developed architecture was trained, tested, and evaluated specifically on the problem of diagnosis of lung cancer nodules found on digitized chest radiographs. The system performs automatic "suspect" localization, feature extraction, and diagnosis of a particular pattern-class aimed at a high degree of "true-positive fraction" detection and low "false-positive fraction" detection. In this paper, the authors aim at the presentation of the two-level neural classification method in reducing false-positives in their system. They employed receiver operating characteristics (ROC) method with the area under the ROC curve (A/sub z/) as the performance index to evaluate all the simulation results. The two-level CNN showed superior performance (A/sub z/=0.93) to the single-level CNN (A/sub z/=0.85). The proposed two-level CNN architecture is proven to be promising and to be extensible, problem-independent, and therefore, applicable to other medical or difficult diagnostic tasks in two-dimensional (2-D) image environments.