The Role of Spatial Complementarity in Chiral Recognition
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 16 (1) , 161-170
- https://doi.org/10.1080/10826079308020904
Abstract
3, 5-Dinitrobenzoyl chloride and the cis and trans isomers of 3, 5-dinitrocinnamoyl chloride were used to acylate a variety of amines. The chromatographic behavior of these derivatives on several π-basic CSPs suggests that a correspondence in the size of the π-basic and π-acidic groups is an important factor in the observed enantioselectivity. As the size of the π-basic group in the CSP increases, the observed enantioselectivity of the N-(3, 5-dinitrocinnamoyl) derivatives also increases.Keywords
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