Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition
- 15 February 2004
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 378 (1) , 213-217
- https://doi.org/10.1042/bj20031193
Abstract
The mechanisms regulating mitochondrial outer-membrane permeabilization and the release of cytochrome c during apoptosis remain controversial. In the present study, we show in an in vitro model system that the release of cytochrome c may occur via moderate modulation of mitochondrial volume, irrespective of the mechanism leading to the mitochondrial swelling. In contrast with mitochondrial permeability transition-dependent release of cytochrome c, in the present study mitochondria remain intact and functionally active.Keywords
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