Human genes encoding prothrombin and ceruloplasmin map to 11p11?q12 and 3q21?24, respectively
- 1 May 1987
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 13 (3) , 285-292
- https://doi.org/10.1007/bf01535211
Abstract
The gene for human prothrombin, or factor II (F2) has been assigned to 11p11–q12 by the combined use of a panel of somatic cell hybrid DNAs and in situ hybridization, using both cDNA and genomic probes. In addition, the cDNA probe for F2 recognizes a homologous sequence which has been tentatively mapped to the X chromosome. Similar approaches have been used to confirm the assignment of the ceruloplasmin gene, but to regionally localize it more proximally than previously reported (3q21–q24). These results provide further evidence that genes encoding the coagulation factors and related proteins are dispersed throughout the human genome.This publication has 22 references indexed in Scilit:
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