A COMPARATIVE STUDY OF THE EFFECT OF ALKYLRESORCINOLS AND RELATED COMPOUNDS UPON THE ABSORPTION OF INSULIN FROM ISOLATED INTESTINAL LOOPS OF ANESTHETIZED DOGS

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Abstract
A comparative investigation of the effect of the alkylresorcinols, ethyl-, propyl-, butyl-, pentyl-, hexyl-, heptyl- and octyl-, upon the absorption of insulin from loops of the upper small intestine of dogs under Na amytal demonstrated that hexylresorcinol is most effective and the lower and higher homologues decreasingly effective. Evidence of insulin absorption was obtained by determining the level of the blood glucose. The effect of these compounds upon insulin absorption was found to compare favorably with the bactericidal action, but could not be correlated with the surface tension lowering properties. The a carbonyl derivatives of the alkylresorcinols and other compounds of similar chemical nature were tested and found ineffective in promoting the absorption of insulin.

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