INCREASED METASTATIC CAPACITY OF LEWIS LUNG-TUMOR CELLS BY INVIVO SELECTION PROCEDURE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 3  (3) , 174-182
Abstract
Lewis [mouse] lung tumors cells from liver metastases originally obtained from an intrasplenic tumor, and lung metastases obtained from an i.m. transplant, were repeatedly passaged in the corresponding transplantion sites (spleen, intramuscular). Cells from liver metastases injected into the spleen gained an increased metastatic capacity. The same phenomenon was observed with lung metastatic cells injected i.m., but to a lesser degree. In all passages metastases occurred only in the organs receiving the veous blood from the primary site. The enhanced metastasis formation may be a result of a selection of tumor cells resistant to host cytotoxic cells and/or of selection of tumor cells seeding successfully in target organs.