Antibiotic Combinations

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Abstract
JAWETZ and his co-workers1 have presented evidence that certain combinations of antibiotics may be less effective in their antibacterial action than comparable amounts of the same agents acting separately. Such "antagonisms" have been demonstrated in vitro and in some experimental infections, mostly in mice, but, except for the report of Lepper and Dowling2 on the possible antagonistic action of chlortetracycline and penicillin in the treatment of pneumococcal meningitis, there has been little or no reliable clinical evidence for such an antagonistic action among antibiotics. Moreover, such evidence is difficult to obtain because of the many problems involved in conducting adequately . . .