N-Alkylation of Amino Acid Esters Using Sodium Triacetoxyborohydride
- 1 April 1996
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 26 (7) , 1379-1384
- https://doi.org/10.1080/00397919608003499
Abstract
N-Alkylation of amino acid esters by reductive amination using sodium cyanoborohydride may often be problematic. Sodium triacetoxyborohydride was found to be a convenient reagent for this transformation. This methodology was employed to alkylate various amino acid methyl esters.Keywords
This publication has 6 references indexed in Scilit:
- Formation of bis (Fmoc-amino ethyl)-N-glycine derivatives by reductive amination of Fmoc-amino aldehydes with NaBH3CNTetrahedron Letters, 1994
- Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydrideTetrahedron Letters, 1990
- Reductive Amination of Aldehydes and Ketones with Weakly Basic Anilines Using Sodium TriacetoxyborohydrideSynlett, 1990
- Synthesis and biological activities of some pseudo-peptide analogs of tetragastrin: the importance of the peptide backboneJournal of Medicinal Chemistry, 1985
- Reactions of sodium borohydride in acidic media. Selective reduction of aldehydes with sodium triacetoxyborohydrideJournal of the Chemical Society, Chemical Communications, 1975
- Sodium Cyanoborohydride - A Highly Selective Reducing Agent for Organic Functional GroupsSynthesis, 1975