Inhibition of Adrenocorticotrophin Secretion During Deprivation-Induced Eating and Drinking in Rats

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Abstract
Rats that were maintained on a 23 h food and water deprivation schedule (food and water available between 0900 and 1000 h) for 21 days and whose blood was sampled at various times following initiation of ingestion showed a decrease in plasma ACTH concurrent with dropping plasma levels of corticosterone (COR). This drop occurred from elevated levels of these hormones, most likely due to altered circadian patterns of pituitary-adrenal activity as a result of the rhythm-entraining properties of the feeding schedule. This inhibition of secretion of ACTH is interpreted as reflecting the inhibitory effect of a CNS mechanism that can affect ACTH secretion independently of corticosteroid negative feedback.