Complete synthesis of 3′‐sialyl‐N‐acetyllactosamine by regioselective transglycosylation
Open Access
- 2 December 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 399 (3) , 203-206
- https://doi.org/10.1016/s0014-5793(96)01267-7
Abstract
Transglycolytic synthesis of 3′‐sialyl‐N‐acetyllactosamine by sequential use of β‐galactosidase from Bacillus circulans and trans‐sialidase from Trypanosoma cruzi was described. These reactions depicted the first complete synthesis of a biologically important oligosaccharide with high regioselectivity avoiding use of glycosyltransferases and NDP sugars.Keywords
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