Citrovorum Factor and Oviduct Response to Stilbestrol in Aminopterin-Treated Chicks
- 1 January 1951
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 76 (1) , 203-205
- https://doi.org/10.3181/00379727-76-18436
Abstract
Citrovorum Factor (CF) in a ratio to aminopterin of approx. 16:1, but not of 2:1, counteracts aminopterin inhibition of stilbestrol stimulation of the chick oviduct, while pteroylglutamic acid (PGA) in a ratio to aminopterin of 500:1 is 81% effective in this regard. That CF can substitute for PGA in permitting stilbestrol stimulation of the chick oviduct is further evidence consistent with the theory that CF is a metabolically active form of PGA.Keywords
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