Regeneration of peripheral blood cells following ABO incompatible allogeneic bone marrow transplantation for severe aplastic anaemia

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Abstract
The regeneration of peripheral blood cells in 6 patients receiving ABO incompatible bone marrow transplants for severe aplastic anemia has been studied. The results are compared with those of 18 similar aplastic patients treated with ABO compatible transplants. Reticulocyte recovery in the ABO incompatible cases was significantly delayed (P < 0.01) and associated with greatly prolonged red cell transfusion requirements (P < 0.001). Peripheral blood regeneration of neutrophils, lymphocytes and platelets was also significantly delayed (P < 0.01). Platelet support was required for longer in the ABO incompatible cases (P < 0.001), but there was no increase in the incidence or severity of infections in the posttransplant period.