Lipid changes in the perfusates of isolated rabbit hearts

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Abstract
Rabbit hearts were perfused with different media using the Langendorff technique. Concentrations of the different lipid components were determined before and after perfusion. In experiments using hypercholesterolemic serums to perfuse normal hearts the concentrations of unesterified fatty acids (UFA) in the perfusates were above control levels, and esterified fatty acids were decreased. Total cholesterol did not change, free cholesterol increased, thus esterified cholesterol decreased. In about 50% of the experiments in which oleic acid-loaded albumin was used to perfuse normal hearts, an uptake of UFA occurred. Triglycerides were apparently not removed by rabbit hearts even when hypertriglycerolemic serum was the perfusion medium.