SYNTHESIS OF γ‐METHYL‐l‐LEUCINE (NEOPENTYLGLYCINE, NEO) AND DERIVATIVES SUITABLE FOR PEPTIDE SYNTHESIS
- 1 September 1981
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 18 (3) , 249-255
- https://doi.org/10.1111/j.1399-3011.1981.tb02979.x
Abstract
The modified Strecker synthesis of Patel & Worsley was combined with an enzymatic deamidation in the final step, to produce the title compound. The amino acid is a member of the family of the “fat” amino-acids with high lipophilicity and space-filling properties, as estimated by its Hansch hydrophobicity constant and its Charton steric parameter v. It can be used for qualitative and quantitative studies of structure-activity relationships in biologically active peptides. Three of its derivatives suitable for peptide synthesis are also described.Keywords
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