Colostral Immunoglobulin-A: Synthesis in vitro of T-Chain by Rabbit Mammary Gland

Publisher Website
Google Scholar
Abstract
When minced mammary tissue from lactating rabbits was incubated in vitro with C 14 -labeled lysine and isoleucine, it incorporated radioactivity into colostral immunoglobulin A. The only portion of this colostral molecule with significant labeling was T-chain, with little or no labeling of light or heavy chains. It was thus demonstrated that T-chains are synthesized by mammary gland. Because the remainder of the molecule was derived from unlabeled material, in vivo it was probably derived from serum.