DOSE-RESPONSE RELATION FOR ATRACURIUM, ORG NC45 AND PANCURONIUM

Open Access
Publisher Website
Google Scholar
Abstract
The potencies of atracurium, Org NC 45 and pancuronium were determined using cumulative dose-response curves. The effective doses producing 95% twitch depression were 279 μgkg−1, 56 μg kg−1 and 64μg kg−1 respectively, the relative potency being 1:5.0:4.3. The calculated log-probit dose-response curves showed the steepest slope for pancuronium, although the slopes did not deviate significantly from the parallel. The three drugs provided equal and generally good intubating conditions at approximately 95% twitch depression. Greater arterial pressure and heart rate were seen with pancuronium than with atracurium and Org NC45.