RADIOIODINE CONCENTRATION AND THYROID WEIGHT IN NORMAL, OBESE AND DWARF STRAINS OF MICE1

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Abstract
Thyroid activity was measured in Rockland Swiss, obese-hyperglycemic and a strain of mice with a recessive gene for dwarfism. The thyroid glands of the Swiss mice were significantly heavier than those of the other strains and the phenotypic dwarfs had the smallest glands. The greatest I131 uptake occurred in the female Swiss mice and there was relatively little iodine concentration in the dwarf thyroids. However, the phenotypically normal parent stock of the obese or dwarf strains did not differ significantly from the Swiss mice. The phenotypically obese mice tended to concentrate less I131 during a five hour period but the differences were not statistically significant.