Electroconvulsive Shock and Cyclic AMP Signal Transduction: Effects Distal to the Receptor
- 1 June 1986
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 46 (6) , 1667-1669
- https://doi.org/10.1111/j.1471-4159.1986.tb08482.x
Abstract
Chronic electroconvulsive shock (ECS) induced a significant decrease in noradrenaline- and forskolin-stimulated cyclic AMP production in rat cortical slices, whereas a single ECS had a much smaller effect. In a cortical membrane preparation, adenylate cyclase activity in response to stimulation by forskolin, guanosine-5′-(β,γ-imido)triphosphate, and Mn2+ ions was significantly increased in membranes derived from rats that had received chronic ECS, but was either unchanged or reduced in membranes from rats that received a single treatment only. The results are interpreted in terms of changes occurring at components of the adenylate cyclase enzyme distal to the receptor.Keywords
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