Immunologic Analysis of Lymphoid Tumors

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Abstract
During the past decade, the classification of lymphoid tumors has undergone drastic revision. This change was heralded in the 1960's by the discovery that lymphocytes could be divided into thymus-derived (T) and bursa-derived or bone-marrow-derived (B) cells and by evidence indicating that most tumors with lymphoid morphology had origins in one or the other pathway of differentiation.1 Since then, detection of practical markers for human T cells (such as the ability to bind to sheep erythrocytes and surface differentiation antigens) and for B cells (immuno-globulin determinants) has allowed discrimination of tumors affecting these two pathways.2 For example, acute lymphoblastic leukemias, . . .