IMMUNE RESPONSES IN VITRO
Open Access
- 1 March 1972
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 135 (3) , 675-697
- https://doi.org/10.1084/jem.135.3.675
Abstract
The suppressive effects of monospecific goat anti-mouse globulins on primary immunoglobulin class-specific plaque-forming cell responses in mouse spleen cell cultures were investigated. Anti-µ suppressed responses in all immunoglobulin classes, whereas anti-γ1 and anti-γ2 suppressed the γ1 and γ2 responses but not γM or γA responses, and anti-γA suppressed only γA responses. The mechanism of action of the anti-µ was studied in detail because of its suppression of responses in all immunoglobulin classes.Keywords
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