Nitrate production and phagocyte activation: differences among Sprague–Dawley, Wistar‐Furth and Lewis rats

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Abstract
We have found that activated resident peritoneal macrophages from Wistar-Furth and Sprague-Dawley rats produce significantly more superoxide (2.2 ± 0.4 and 3.6 ± 0.8 nmol ofcytochrome c reduced/106 cells/10 min respectively) than those from Lewis rats (1.0 ± 0.3 nmol of cytochrome c reduced/106 cells/10 min). Similar results are found in macrophages elicited with intraperitoneal thioglycolate. Furthermore, nitrate excreted in the urine increased greatly wheneither Wistar—Furth or Sprague—Dawley rats are injected i.p. with iota carrageenan (0.25 g), a response that did not occur with Lewis rats. This strain difference in the manifestations of the Inflammatory response correlates with previous observations that Wistar—Furth and Sprague—Dawley rats, but not Lewis rats, develop suture-line colonic tumors when the ureters and bladder base are implanted into the colon.