The formation of glycine and serine. The influence of the administration of glycine, dl-serine and other compounds on levels of tissue glycine and serine

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Abstract
The influence of the administration of benzoate, glycine, DL-serine, acetate, pyruvate or DL-[beta]-hydroxybutyrate on the concentrations of free glycine and free L-serine in the liver and blood of the rat and the blood of the rabbit was investigated. Administration of glycine resulted in a rise in the concentration of both glycine and serine. Administration of serine or its non-nitrogenous precursors resulted in a rise in the concentration of serine but not of glycine. Administration of benzoate alone resulted in a fall in the concentration of glycine but not of serine. The significance of the results is discussed with reference to the kinetics of the inter-conversion of glycine and serine.