Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection
Open Access
- 17 May 2007
- journal article
- Published by Springer Nature in Respiratory Research
- Vol. 8 (1) , 38
- https://doi.org/10.1186/1465-9921-8-38
Abstract
Developing strategies for controlling the severity of pandemic influenza is a global public health priority. In the event of a pandemic there may be a place for inexpensive, readily available, effective adjunctive therapies to support containment strategies such as prescription antivirals, vaccines, quarantine and restrictions on travel. Inactivation of virus in the intranasal environment is one possible approach. The work described here investigated the sensitivity of influenza viruses to low pH, and the activity of low pH nasal sprays on the course of an influenza infection in the ferret model.Keywords
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