Secretory effects of cholecystokinins on the isolated perfused porcine pancreas

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Abstract
Three different molecular forms of cholecystokinin (CCK-39, -33, and -8) were used in concentrations from 10-11 to 10-8 mol/l to stimulate the endocrine and exocrine secretion from the isolated perfused porcine pancreas. During perfusion with a glucose concentration of 7.5 mmol/l CCK-39 in the highest concentration increased the insulin secretion slightly. No significant effect was observed at lower glucose concentrations (5.0 and 3.5 mmol/l). CCK-33 and -8 did not stimulate the secretion of insulin significantly, and neither of the cholecystokinins increased the secretion of glucagon and bicarbonate. All 3 molecular forms stimulated the secretion of fluid and protein in concentrations above 10-11 mol/l in a dose-dependent manner and with equal potency. The effect of these 3 cholecystokinins on the endocrine pancreas is without physiological significance; all 3 are sufficiently potent to play a role in the control of pancreatic protein secretion.