Comparative studies of physicochemical and biological properties between canine parvovirus and feline panleukopenia virus.

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Abstract
The properties of canine parvovirus (CPV) and feline panleukopenia virus (FPLV) were compared by means of physicochemical treatments, biological tests and experimental infection of domestic dogs and cats or specific pathogen-free (SPF) cats. No distinct difference between CPV and FPLV was observed in their physicochemical properties. The difference between CPV and FPLV in range of host cells and in hemagglutination could be confirmed in this study. CPV was inactivated by heating at 80.degree. C for 1 h as compared to the inactivation of FPLV at 80.degree. C for 2 h. The physical map of CPV differed from that of FPLV at both ends of DNA digested with BglIII and HindIII, though the 2 central fragments were common to the viruses. Experimental infection of domestic dogs with CPV or FPLV, and domestic cats with CPV produced clinical signs of the disease; CPV-inoculated SPF cats did not show any symptoms. All the experimental animals, with or without clinical signs, produced hemagglutination-inhibiting antibodies to the virus.