A High Incidence Antibody (Anti‐Sc3) in the Serum of a Sc:—1,—2 Patient

Abstract
An individual was found whose red blood cells type as Sc:-1,-2 and do not absorb or yield on elution, anti-Sc1 or anti-Sc2. The patient produced an antibody reacting with all red blood cells, except those that were Sc:-1,-2. The antibody called anti-Sc3 did not contain separable specificities when absorption studies were performed with Sc:-1,2 and Sc:1-2 red blood cells. It appears that all Sc:1 or Sc:2 red blood cells are also Sc:3, while those that are Sc:-1-2, are Sc:-3. A family study did not reveal the genetic background responsible for this Sc:-1,-2 phenotype.