Prostaglandins Enhance Intercellular Adhesion of Vero Cells Infected with Herpes Simplex Virus

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Abstract
The effect of prostaglandins (PG) and cyclic nucleotides on adherence between uninfected African green monkey kidney Vero cells or between uninfected cells and cells infected with wild-type or syncytial strains of herpes simplex virus (HSV) was studied. In the absence of serum, PGE2 increased adhesion between uninfected cells; PGF2.alpha. decreased it. Both PGE2 and PGF2.alpha. increased adhesion between cells infected with HSV and uninfected cells. Dibutyryl cAMP increased adhesion between uninfected cells and cells infected with HSV; dibutyryl cGMP decreased it.