The infrared spectrum and structure of the type I complex of silver and DNA
Open Access
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 13 (1) , 251-260
- https://doi.org/10.1093/nar/13.1.251
Abstract
Infrared spectroscopy was used to study films of the type I complex of Ag+ and DNA as a function of hydration with the following conclusions. (1) Ag+ binds to guanine residues but not to cytosine or thymine residues. (2) Cytosine becomes protonated as Ag+ binds to guanine. (These conclusions confirm previous models.) (3) The type I complex remains in the B family of structures with slight modifications of the sugar-phosphate geometry. (4) This modified B structure remains stable at lower values of hydration for which pure DNA is in the A form. (5) Binding of Ag+ to PO2 O-P-O or the deoxyribose oxygen is excluded.Keywords
This publication has 12 references indexed in Scilit:
- The Anatomy of A-, B-, and Z-DNAScience, 1982
- Solution structural studies of the Ag(I)-DNA complexNucleic Acids Research, 1981
- Electric dichroism and sedimentation velocity studies of DNA-Hg(II) and DNA-Ag(I) complexesBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980
- A new conformation-specific infrared band of A-DNA in filmsNucleic Acids Research, 1980
- Circular dichroism anisotropy of DNA with different modifications at N7 of guanineBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979
- Infidelity of DNA Synthesis in Vitro: Screening for Potential Metal Mutagens or CarcinogensScience, 1976
- Studies of heavy metal binding with polynucleotides using optical detection of magnetic resonance. Silver(I) bindingJournal of the American Chemical Society, 1975
- A new approach to the characterization of the B and A forms of DNA by I.R. spectroscopyBiochemical and Biophysical Research Communications, 1973
- The infrared spectra of some complexes of metal ions with nucleosides and nucleotidesBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967
- The Tautomeric Form of Helical Polyribocytidylic AcidJournal of the American Chemical Society, 1965