Hypertension of Renal Origin: Evidence for Two Different Mechanisms
- 24 December 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4016) , 1344-1346
- https://doi.org/10.1126/science.174.4016.1344
Abstract
Antibody to angiotensin 11, or a specific peptide competitive inhibitor of angiolensin II, was used to investigate the role of the renin-angiotensin system in two types of renal hypertension in rats. The data indicate that angiotensin II is in fact critically involved in the pathogenesis of the form of renal hypertension in which one renal artery is clamped and the contralateral kidney is left in place, but that it probably plays no significant role in the maintenance of experimental renal hypertension in which the opposite kidney has been removed.Keywords
This publication has 13 references indexed in Scilit:
- Angiotensin II Vascular Receptors: Their Avidity in Relationship to Sodium Balance, the Autonomic Nervous System, and HypertensionJournal of Clinical Investigation, 1972
- Effect of Sodium Restriction on Renal Hypertension and on Renin Activity in the RatCirculation Research, 1970
- A Specific Competitive Inhibitor of Angiotensin IIProceedings of the National Academy of Sciences, 1970
- Renal-Clip Hypertension in Rabbits Immunized Against Angiotensin IICirculation Research, 1970
- Renal Hypertension in Rabbits Immunized with Angiotensin - IIScandinavian Journal of Clinical and Laboratory Investigation, 1970
- Studies on the role of angiotensin in experimental renovascular hypertension: an immunologic approachJournal of Clinical Investigation, 1969
- News from the American Heart AssociationCirculation Research, 1969
- Effect of rabbit antibodies against angiotensin‐II on the pressor response to angiotensin‐II and renal hypertension in the ratBritish Journal of Pharmacology, 1968
- Influence of the Gastrointestinal Iodide Cycle on the Early Distribution of Radioactive Iodide in Man *Journal of Clinical Investigation, 1965
- STUDIES ON EXPERIMENTAL HYPERTENSIONThe Journal of Experimental Medicine, 1934