Macroaggregated albumin studies of the coronary circulation in the dog.

  • 1 March 1973
    • journal article
    • Vol. 14  (3) , 129-34
Abstract
The distribution, toxicity, and clearance of 131I-labeled macroaggregated albumin were studied in the coronary circulation of the dog. Twenty-five percent of the injected label traversed the coronary capillary bed within 3 min after injection and the biologic half-clearance time of the remainder was approximately 8 hr. After coronary artery injection of macroaggregate, no deterioration of left ventricular function was apparent from hemodynamic measurements, and no histologic evidence of myocardial damage was found after doses up to ten times the suggested diagnostic dose. The results of computer-controlled external scintiscans in the excised heart were shown as three-dimensional displays of count distribution.