THE EFFECT OF LONGTERM ADMINISTRATION OF PYROGALLOL ON THE METABOLISM OF CATECHOLAMINES

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Abstract
The rate of excretion of O-methylated derivatives of catecholamines in the urine decreased briefly during the administration of pyrogallol, but after longterm treatment with pyrogallol it returned to the normal rate. Daily treatment with pyrogallol increased the rate of excretion of free catecholamines in the urine and the rate of excretion reached a maximum after 3 weeks. Longterm treatment with pyrogallol increased the activities of O-methyltransferase and monoamine oxidase in the liver. These results suggest that enzyme activities related to the regulation of catecholamines in the body are adaptively altered by changes in the endogenous catecholamine level.