Inhibitor of O-Methylation of Epinephrine and Norepinephrine in vitro and in vivo
- 25 September 1959
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 130 (3378) , 800
- https://doi.org/10.1126/science.130.3378.800
Abstract
Pyrogallol inhibits the O-methylation of epinephrine and norepinephrine by catechol-O-methyl transferase in vitro as well as the metabolism of these catecholamines, and the formation of their O-methylated metabolites, in the intact mouse. Since pyrogallol also prolongs the physiological effects of epinephrine, it is suggested that catechol-O-methyl transferase terminates the actions of the catecholamine hormones.Keywords
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