IRON ABSORPTION IN THE ABSENCE OF BILE

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Abstract
Fe absorption was studied in dogs with anastomoses of the gall bladder to the right renal pelvis and ligation of the common bile duct, using normal animals as controls. The Fe was given by mouth, with and without food, olive oil, and mineral oil. As judged by the increase in plasma Fe levels, the dog with internal bile fistula absorbs iron as well as the normal animal after ferrous sulfate or gluconate is given by mouth. No rise in plasma iron occurs within 24 hrs. after giving Fe mixed with food to either normal or bile fistula dogs. Continued adm. of Fe with food over several days causes an increase in plasma Fe in both types of animals. Olive oil given with Fe prevents the rise of plasma Fe in bile fistula but not in normal dogs; mineral oil has little if any effect. The anemia of the bile fistula dog is evidently not due to an Fe deficiency; this is further substantiated by the fact that avg. fasting plasma Fe levels in bile fisula and normal dogs show no significant differences.

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