Fatal Polymyositis in D-Penicillamine-Treated Rheumatoid Arthritis
- 1 March 1983
- journal article
- case report
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 98 (3) , 327-330
- https://doi.org/10.7326/0003-4819-98-3-327
Abstract
Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment with D-penicillamine are reviewed and a fourteenth case is described. Twelve of the fourteen patients recovered after D-penicillamine was withdrawn; two patients died from cardiac involvement. Proximal muscle weakness was present in 13 patients and dermatomyositis in 4 patients. Dysphagia was the presenting symptom in 6 patients. Although D-penicillamine is useful in the management of rheumatoid arthritis, this drug should be used with caution and patients monitored closely for evidence of polymyositis or dermatomyositis.Keywords
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