α‐Dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy
Open Access
- 22 August 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 350 (2-3) , 173-176
- https://doi.org/10.1016/0014-5793(94)00748-9
Abstract
The dystrophin—glycoprotein complex was examined in dystrophin‐deficient dogs with golden retriever muscular dystrophy (GRMD) using immunoblot and immunofluorescence analysis. The dystrophin‐associated proteins were substantially reduced in muscle from dogs with GRMD. Interestingly, regression analysis revealed a strong correlation between the amount of α‐dystroglycan and serum creatine kinase levels and the contraction tension measured for a given peroneus longus muscle.Keywords
This publication has 39 references indexed in Scilit:
- Identification and purification of an agrin receptor from torpedo postsynaptic membranes: A heteromeric complex related to the dystroglycansNeuron, 1994
- Glycoprotein‐binding site of dystrophin is confined to the cysteine‐rich domain and the first half of the carboxy‐terminal domainFEBS Letters, 1992
- An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophyGenomics, 1992
- Expression of the N‐terminal domain of dystrophin in E. coli and demonstration of binding to F‐actinFEBS Letters, 1992
- Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrixNature, 1992
- Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma.The Journal of cell biology, 1991
- Muscular dystrophy in a litter of golden retriever dogsMuscle & Nerve, 1988
- Characterization of Dystrophin in Muscle-Biopsy Specimens from Patients with Duchenne's or Becker's Muscular DystrophyNew England Journal of Medicine, 1988
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970