Protein processing map of poliovirus

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Abstract
Five previously unmapped proteins (5a, 7d, 8, 9b and 10) were located on the proteolytic processing map of the polyprotein. One of the proteins, 9b, appears to be the sister fragment of a cleavage reaction (P3-9 .fwdarw. P3-9b + VPg). Two of the other newly mapped proteins, 8 and 10, have been identified as sister fragments of X-related proteins 3b and 5b; thus, P2-3b .fwdarw. P2-8 + P-25b and P2-5b .fwdarw. P2-10 + P2-X. The remaining proteins, 5a and 7d, mapped in the 1b protein and appear to result from the cleavages P3-1b .fwdarw. P3-5a + P3-6b and P3-4b .fwdarw. P3-7d + P3-6b. These assignments account for > 95% of the total polioviral proteins and complete the mapping of the major processing pathways.