Newer Methods for Evaluating Thyroid Nodules

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Abstract
The usefulness of classifying thyroid nodules according to their capacity for accumulating radioiodine as revealed by scintiscans is well established; thyroid cancer occurs much more frequently in nonfunctioning or "cold" nodules than in "hot" nodules. Nonfunctioning thyroid nodules, however, constitute a heterogeneous group that includes adenomas, cysts, subacute and chronic thyroiditis, multinodular goiter, various fibrotic, hemorrhagic and necrotic processes, in addition to thyroid neoplasia; cancer, indeed, accounts for only a minority of hypofunctioning or nonfunctioning nodules. Characterization of "cold" nodules to provide better discrimination between benign and malignant disorders has been attempted in several ways, including measurement of uptake of . . .