STUDIES IN METHIONINE AND SULFUR METABOLISM. I. THE FATE OF INTRAVENOUSLY ADMINISTERED METHIONINE, IN NORMAL INDIVIDUALS AND IN PATIENTS WITH LIVER DAMAGE 12

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Abstract
DL-methionine was intraven. administered to normal individuals and to patients with acute and chronic liver disease in a dose of 50 cc. of 3% soln. over a 5-min. period. The blood and urine contents were determined microbiologically prior to methionine admn. and at intervals of 15, 30, 60, 120 and 180 min. post-methionine. Urinary sulfate was also determined during the exptl. period. Patients with severe liver damage remove methionine from the plasma less rapidly than do normal individuals. No significant difference in urinary D-or L-methionine was noted between the normal and the patient with liver damage. Insignificant amts. of L-methionine appeared in the urine but considerable amts. of D-methionine were found in all instances. A few individuals with very severe liver damage had marked increase in urinary sulfate which was interpreted as indicating excessive methionine catabolism.