Effects of slice selection and diffusion on T2 measurement

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Abstract
This study examines slice selection and diffusion as sources of systematic error in T2 estimates obtained from imaging experiments. The selective refocusing pulses in a multislice, two-echo, spin-warp experiment cause slice profiles of sequential echoes to change in shape. This results in bias in T2 images calculated from the two-echo data set. A method to correct the bias is presented. The effect of diffusion on T2 images obtained with typical two-echo imaging sequences was found to be negligible. © 1987 Academic Press, Inc.