Heparin-Induced Thrombocytopenia: Pathophysiology and Management
- 1 May 2002
- journal article
- review article
- Published by SAGE Publications in Vascular and Endovascular Surgery
- Vol. 36 (3) , 163-170
- https://doi.org/10.1177/153857440203600302
Abstract
Immune-mediated heparin-induced thrombocytopenia (HIT) is a well-defined syndrome. Clinical criteria (thrombocytopenia, resistance to heparin anticoagulation, or thromboses during heparin therapy) are defined, and serologic diagnostic tests are available. Earlier recognition of HIT syndrome has allowed for significant advances in therapy, leading to marked reductions in morbidity and mortality from HIT syndrome. This review addresses the epidemiology, pathobiology, and management of HIT syndromeKeywords
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