Non-Watson-Crick G ⋅ C and A ⋅ T Base Pairs in a DNA-Antibiotic Complex
- 6 June 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 232 (4755) , 1255-1258
- https://doi.org/10.1126/science.3704650
Abstract
The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A.T and two G.C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G.C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.This publication has 10 references indexed in Scilit:
- A structural basis for S1 nuclease sensitivity of double-stranded DNACell, 1985
- A comparison of the structure of echinomycin and triostin A complexed to a DNA fragmentNucleic Acids Research, 1985
- Sequence preferences in the binding to DNA of triostin A and TANDEM as reported by DNase I footprintingFEBS Letters, 1984
- The Molecular Structure of a DNA-Triostin A ComplexScience, 1984
- Echinomycin Binding Sites on DNAScience, 1984
- THE CHEMISTRY AND BIOLOGY OF LEFT-HANDED Z-DNAAnnual Review of Biochemistry, 1984
- Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequencesNucleic Acids Research, 1984
- A new model for DNA containing A.T and I.C base pairs.The EMBO Journal, 1982
- Molecular structure of a left-handed double helical DNA fragment at atomic resolutionNature, 1979
- The Tautomeric Form of Helical Polyribocytidylic AcidJournal of the American Chemical Society, 1965