Atrial natriuretic factor regulation of cyclic GMP levels and steroidogenesis in isolated fasciculata cells of rat adrenal cortex
- 7 April 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 199 (1) , 121-124
- https://doi.org/10.1016/0014-5793(86)81236-4
Abstract
Isolated fasciculata cells of rat adrenal cortex, when incubated with atrial natriuretic factor (ANF), stimulated the levels of cyclic GMP and corticosterone production in a concentration‐dependent manner without a rise in the levels of cyclic AMP. The ANF‐dependent elevation of cyclic GMP was rapid, with a detectable increment in 30 s. ANF also stimulated the particulate guanylate cyclase. These results not only indicate the coupling of cyclic GMP and corticosterone production with ANF signal, but also demonstrate that, like the ACTH signal, cyclic AMP is not the mediator of ANF‐induced adrenocortical steroidogenesis.Keywords
This publication has 16 references indexed in Scilit:
- The biochemistry and molecular biology of atrial natriuretic factorBiochemical Journal, 1985
- Effects of atriopeptin on particulate guanylate cyclase from rat adrenalBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985
- Distinct atrial natriuretic factor receptor sites on cultured bovine aortic smooth muscle and endothelial cellsBiochemical and Biophysical Research Communications, 1985
- Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.Proceedings of the National Academy of Sciences, 1984
- Specific receptors for atrial natriuretic factor (ANF) in cultured vascular smooth muscle cells of rat aortaBiochemical and Biophysical Research Communications, 1984
- Isolation and sequence determination of peptide components of atrial natriuretic factorBiochemical and Biophysical Research Communications, 1984
- Adrenocorticotropin-dependent particulate guanylate cyclase in rat adrenal and adrenocortical carcinoma: Comparison of its properties with soluble guanylate cyclase and its relationship with ACTH-induced steroidogenesisArchives of Biochemistry and Biophysics, 1982
- Relationship of Calcium and Membrane Guanylate Cyclase in Adrenocorticotropin-Induced Steroidogenesis*Endocrinology, 1982
- Steroidogenesis in Isolated Adrenal Cells of Rat. III. Morphological and Biochemical Correlation of Cholesterol and Cholesterol Ester Content in ACTH and N6-2′-0-Dibutyryl-Adenosine-3′,5′-Monophosphate Activated Adrenal CellsEndocrinology, 1972
- Corticosteroidogenesis in Isolated Adrenal Cells of Rats. I. Effect of Corticotropins and 3′,5′-Cyclic Nucleotides on Corticosterone ProductionEndocrinology, 1971