The role of 5‐hydroxytryptamine and noradrenaline in the hyperthermic reaction induced by pethidine in rabbits pretreated with pargyline

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Abstract
1 Inhibition of 5-hydroxytryptamine (5-HT) synthesis by p-chlorphenylalanine protected rabbits pretreated with pargyline from the fatal hyperthermic reaction which occurs on the intravenous injection of pethidine. 2 The development of tolerance to morphine did not protect against the fatal pargyline-pethidine hyperpyrexia. Moreover, the injection of nalorphine before or after pethidine conferred no protection. 3 Pethidine evoked a hyperpyrexia in rabbits pretreated with lithium sulphate or yohimbine. 4 Sodium diethyldithiocarbamate caused a fatal hyperpyrexia in rabbits pretreated with pargyline. 5 It is concluded that the pargyline-pethidine hyperthermic interaction might involve the relative concentrations of 5-HT and noradrenaline in the hypothalamus.