Detection of Apoptotic Fetal Cells in Plasma of Pregnant Women
Open Access
- 1 May 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 46 (5) , 729-731
- https://doi.org/10.1093/clinchem/46.5.729
Abstract
Fetal DNA is present in plasma of pregnant women in amounts almost 1000-fold higher than the DNA present in intact fetal cells circulating in maternal peripheral blood ( 1)( 2). The clinical usefulness of fetal DNA from plasma for noninvasive prenatal diagnosis has been demonstrated recently through analysis of the fetal RhD status by PCR-based approaches ( 3)( 4)( 5). We explored the possibility that not all of this fetal DNA is soluble and cell-free, but that part of it is still cell-associated.Keywords
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