Metabolism of Putrescine in Neuroblastoma and Glioma Cells during Culture1

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Abstract
The metabolism of putrescine in neuroblastoma and glioma cells was analyzed during culture. In the former cells the formation of γ-aminobutyric acid from putrescine was low and constant during the logarithmic phase and increased dramatically during the stationary phase or in cultures with low serum concentrations, while in the latter cells it was low and constant throughout culture. The formation of spermidine from putrescine in both cell lines was active at days 1–2 of culture and decreased gradually during culture. These findings indicate that spermidine formation is closely related to proliferation of the cells, and γ-aminobutyric acid formation to differentiation or maturation of the neuroblastoma cells.