Pituitary Stimulating Substance in Brain Blood of Hypophysectomized Rat Following Electric Shock "Stress".

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Abstract
Brain blood from "stressed" and "unstressed" hypophysectomized rats was injected into rats bearing hypothalamic lesions, and also into hypophysectomized and adrenalectomized rats. When brain blood from stressed hypophysectomized rats was injected into lesioned rats, a marked eosinopenia occurred; this did not occur when unstressed brain blood was injected into these same lesioned rats. This eosinopenia depended upon the presence of an intact pituitary-adrenal axis. It is concluded that the brain blood following stress possesses pituitary stimulating activity which is not present in brain blood from unstressed animals.