Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 57 (1) , 39-42
- https://doi.org/10.1007/bf00426955
Abstract
Three centrally active inhibitors of phenylethanolamine-N-methyl transferase (PNMT; E.C.2.1.1.28), the terminal enzyme for epinephrine biosynthesis in the brain, produced dose-related decreases in rates of responding for rewarding brain stimulation in adult male rats. Decreases occurred at dosages that did not produce measurable neurologic impairment. This suggests a possible role for central epinephrine-containing neurons in the maintenance of reward-mediated behaviors.Keywords
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